Manchester United face Chelsea at Stamford Bridge in the biggest Premier League clash of the weekend.
Mourinho is fighting for his job and needs a good result against his former team to follow the dramatic comeback against Newcastle before the international break.
Otherwise the writing looks on the wall for the Portuguese.
It was reported that Mourinho was set for the axe whatever the result against Newcastle but he has survived an international break dismissal.
However Sky Italia journalist Federico Zancan says Mourinho could be sacked before United play Juventus in the Champions League next week, if they suffer a heavy defeat to Chelsea.
He said: “The victory against Newcastle has hidden them from the problems, but this Saturday at Stamford Bridge ( against Chelsea ) is a serious game and then there will be the one in the Champions League against Juventus.
“Exoneration before Juventus would take a very heavy defeat. The relationships are not solid with the company and some other negative result could also lead to the removal of Mourinho even if at this moment it is difficult to think of such fast timings.
“It must be said that United are pretty far behind in the league and has not yet faced any big team in Premier League except Tottenham who won 3-0 at Old Trafford.
“These close encounters that will define the season and career at Old Trafford by Mourinho are very important. ”
United have struggled this term after a difficult transfer window in the summer where Mourinho wanted more additions to his squad after finishing second behind Manchester City.
However he only managed to bring in Diogo Dalot, Lee Grant and Fred despite wanting a central defender and a winger.
And United have been a mess at the back and have already lost to West Ham, Derby, Tottenham and Brighton this season.